Medical symbolDirectory of Drugs: Prescription symbol Zylet - loteprednol etabonate; tobramycin



Brand Name: Zylet®
Active Ingredient: loteprednol etabonate (0.5%) and tobramycin (0.3%)
Strength(s): 2.5 mL in 7.5 mL bottle; 5 mL in 7.5 mL bottle; 10 mL in 10 mL bottle
Dosage Form(s): ophthalmic (eye) suspension
Company Name: Bausch & Lomb, Inc.
Availability: Prescription only
Date Approved by FDA: December 14, 2004


What is Zylet used for?        

Zylet is an eye drop medicine that is used to treat certain eye inflammation and where there is a bacterial infection of the eye or the chance of a bacterial infection in the eye.  Zylet contains a corticosteroid medicine and an antibiotic medicine.

Zylet has not been approved for use in children

Who should not use Zylet?  Who should not be treated with Zylet?          

Do not use Zylet if you:

  • have an eye infection caused by a virus
  • have an eye infection caused by a fungus
  • have an eye infection caused by  a bacteria called mycobacteria
  • Are allergic to corticosteroid medicines or to aminoglycoside antibiotics, or to any of the ingredients in Zylet

 Special Warning(s) with Zylet:         

  • Do not inject Zylet into your eyes.  Zylet is an eye drop medicine.
  • Do not use Zylet for a longer than prescribed by your health care provider. Long-term use of Zylet may cause increased eye pressure, glaucoma, changes in vision, cataracts, and worsen an eye infection.  Your healthcare provider should check your eyes if you need to use Zylet for 10 days or longer.
  • Zylet should not be used after cataract surgery because it may delay healing.
  • Talk with your health care provider if you have a history of herpes simplex, chicken pox virus, or other viral infections of the eye.

General Precautions with Zylet:

  • Call your healthcare provider right away if you have a change in vision, redness, swelling or inflammation, itching, or pain in the eye.

  • Call your healthcare provider if your signs and symptoms do not get better after 2 days of using Zylet.

  • Keep the Zylet eye dropper tip clean and do not allow it to touch anything.

  • Do not wear soft contact lenses when using Zylet because Zylet contains a preservative that is absorbed by soft contact lenses.

What should I tell my health care provider?

Tell your health care provider if you:

  • have glaucoma

  • wear soft contact lenses

  • have had recent cataract surgery

  • are pregnant, are trying to become pregnant, or are breast-feeding

Tell your healthcare provider about all the medicines you are using, especially other eye medicines.

What are some possible side effects of Zylet? (This list is NOT a complete list of side effects reported with Zylet.  Your health care provider can discuss with you a more complete list of side effects.) 

Some common side effects with ZYLET include:

  • breakdown of the surface of the cornea in the eye
  • increased pressure in the eye
  • headache
  • burning and stinging of the eye
  • itching, swelling, and redness of the eye
  • other bacterial or fungal infections

Date created: February 16, 2005


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