Medical symbolDirectory of Drugs: Prescription symbol AmphadaseŽ - hyaluronidase injection



Brand Name: Amphadase®
Active Ingredient: hyaluronidase injection, USP
Strength(s): 150 USP units
Dosage Form(s): injection - not recommended for IV use
Company Name: Amphastar Pharmaceuticals, Inc. 
Availability: Prescription only
Date Approved by FDA: October 26, 2004


What is Amphadase used for?         

Amphadase is an enzyme that is used:

  •  with certain other injected medicines to help them pass into the body faster

  •  to inject under the skin in a process to replace lost fluids in the body when a person is unable to eat or drink

  • to help remove contrast dye from the body when given under the skin for a procedure called urography

Who should not use Amphadase?    

Do not use Amphadase if you are allergic to Amphadase or any of the ingredients in Amphadase.

Special Warning(s) with Amphadase:

  • Amphadase is not for use with all injected medicines.
  • Amphadase should not be injected into or around an area that is infected because it may cause the infection to spread.
  • Amphadase should not be used to reduce the swelling of bug bites or stings
  • Amphadase should not be applied directly to the eye (cornea).
  • Amphadase should not be injected into a vein because it will not work when used this way.

What should I tell my health care provider?

Tell your health care provider if you are pregnant, are trying to become pregnant, or are breast-feeding.

Tell your health care provider if you develop a rash, hives, itching, or swelling after being given Amphadase. 

Tell your health care provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.  Amphadase and other medicines may interact with each other Especially tell your health care provider if you take:

  • salicylates

  •  ACTH

  • estrogens

  • antihistamines

  • corticosteroids

What are some possible side effects of Amphadase? (This list is NOT a complete list of side effects reported with Amphadase.  Your health care provider can discuss with you a more complete list of side effects.)

Some common side effects with Amphadase include:

  • injection site reactions (such as pain at the injection site)
  • swelling
  • itching

Date created: 2/28/05



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